Expression of COL8A2 in cancer - Summary - The Human Protein Atlas

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COL8A2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COL8A2
Gene description	Collagen, type VIII, alpha 2
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ, THP-1, U-138 MG)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA049788
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (unfavourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049788

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	A rare case of melanoma displayed strong membranous staining. Moderate nuclear positivity was observed in a rare case of melanoma, stomach and testicular cancer. A case of ovarian cancer displayed moderate cytoplasmic staining. Remaining cancer tissues were negative.

GENE INFORMATION
Gene name	COL8A2 (HGNC Symbol)
Synonyms	FECD, FECD1, PPCD, PPCD2
Description	Collagen, type VIII, alpha 2 (HGNC Symbol)
Entrez gene summary	This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	36095236 - 36125220
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171812 (version 83.38)
Entrez gene	1296
UniProt	P25067 (UniProt - Evidence at protein level)
neXtProt	NX_P25067
Antibodypedia	COL8A2 antibodies

PROTEIN BROWSER

COL8A2-001	COL8A2-002	COL8A2-201	COL8A2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL8A2-001 ENSP00000380901 ENST00000397799	P25067 [Direct mapping] Collagen alpha-2(VIII) chain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005604 [basement membrane] GO:0005788 [endoplasmic reticulum lumen] GO:0016337 [single organismal cell-cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0030674 [protein binding, bridging] GO:0031012 [extracellular matrix] GO:0048593 [camera-type eye morphogenesis] GO:0050673 [epithelial cell proliferation] Show all	703 aa 67.2 kDa	Yes	0
COL8A2-002 ENSP00000436433 ENST00000481785	E9PP49 [Direct mapping] Collagen alpha-2(VIII) chain; Collagen type VIII alpha 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] Show all	638 aa 60.7 kDa	No	0
COL8A2-201 ENSP00000305913 ENST00000303143	P25067 [Direct mapping] Collagen alpha-2(VIII) chain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001525 [angiogenesis] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005604 [basement membrane] GO:0005788 [endoplasmic reticulum lumen] GO:0016337 [single organismal cell-cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0030674 [protein binding, bridging] GO:0031012 [extracellular matrix] Show all	703 aa 67.2 kDa	Yes	0
COL8A2-202 ENSP00000484406 ENST00000615990	Q4VAQ0 [Direct mapping] COL8A2 protein; Collagen alpha-2(VIII) chain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] Show all	427 aa 42.5 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.