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RPS21

GENERAL INFORMATION

Gene name

 RPS21

Gene description

 Ribosomal protein S21

Protein class

 Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003371
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003371

GENE INFORMATION

Gene name

 RPS21 (HGNC Symbol)

Synonyms

 S21

Description

 Ribosomal protein S21 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 62387116 - 62388520

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171858 (version 83.38)

Entrez gene

 6227

UniProt

 P63220 (UniProt - Evidence at protein level)

neXtProt

 NX_P63220

Antibodypedia

 RPS21 antibodies

PROTEIN BROWSER
RPS21-001
RPS21-002
RPS21-003
RPS21-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS21-001
ENSP00000345957
ENST00000343986
P63220 [Direct mapping]
40S ribosomal protein S21
Q6FGH5 [Target identity:100%; Query identity:100%]
RPS21 protein; Ribosomal protein S21; Ribosomal protein S21, isoform CRA_d
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Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000461 [endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015935 [small ribosomal subunit]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0042274 [ribosomal small subunit biogenesis]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0047485 [protein N-terminus binding]
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 83 aa
9.1 kDa 		No 0
RPS21-002
ENSP00000359593
ENST00000370562
Q9BYK2 [Direct mapping]
40S ribosomal protein S21; Ribosomal protein S21, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000461 [endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0042274 [ribosomal small subunit biogenesis]
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 66 aa
7.1 kDa 		No 0
RPS21-003
ENSP00000359624
ENST00000370592
Q9BYK1 [Direct mapping]
40S ribosomal protein S21; Ribosomal protein S21, isoform CRA_e
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000461 [endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0042274 [ribosomal small subunit biogenesis]
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 90 aa
9.9 kDa 		No 0
RPS21-201
ENSP00000388332
ENST00000450116
Q8WVC2 [Direct mapping]
40S ribosomal protein S21
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000461 [endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0042274 [ribosomal small subunit biogenesis]
Show all
 81 aa
8.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.