Expression of CYP4F11 in cancer - Summary - The Human Protein Atlas

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CYP4F11

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CYP4F11
Gene description	Cytochrome P450, family 4, subfamily F, polypeptide 11
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, EFO-21, Hep G2)
HPA (normal tissue):	Tissue enhanced (gallbladder, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in liver, gallbladder, small intestines and kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA017265 , HPA058960 , CAB033648
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and pancreatic cancer (unfavourable).
Breast cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017265	HPA058960	CAB033648

GENE INFORMATION
Gene name	CYP4F11
Synonyms
Description	Cytochrome P450, family 4, subfamily F, polypeptide 11 (HGNC Symbol)
Entrez gene summary	This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	15912367 - 15934867
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171903 (version 83.38)
Entrez gene	57834
UniProt	Q9HBI6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBI6
Antibodypedia	CYP4F11 antibodies

PROTEIN BROWSER

CYP4F11-001	CYP4F11-002	CYP4F11-003	CYP4F11-004	CYP4F11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP4F11-001 ENSP00000384588 ENST00000402119	Q9HBI6 [Direct mapping] Phylloquinone omega-hydroxylase CYP4F11 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0006954 [inflammatory response] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0020037 [heme binding] GO:0042361 [menaquinone catabolic process] GO:0042376 [phylloquinone catabolic process] GO:0042377 [vitamin K catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	524 aa 60.1 kDa	Yes	0
CYP4F11-002 ENSP00000319859 ENST00000326742	F8W978 [Direct mapping] Phylloquinone omega-hydroxylase CYP4F11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	454 aa 52.2 kDa	Yes	0
CYP4F11-003 ENSP00000476972 ENST00000591841	V9GYP6 [Direct mapping] Phylloquinone omega-hydroxylase CYP4F11 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	199 aa 22.8 kDa	No	0
CYP4F11-004 ENSP00000248041 ENST00000248041	Q9HBI6 [Direct mapping] Phylloquinone omega-hydroxylase CYP4F11 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0006954 [inflammatory response] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0020037 [heme binding] GO:0042361 [menaquinone catabolic process] GO:0042376 [phylloquinone catabolic process] GO:0042377 [vitamin K catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	524 aa 60.1 kDa	Yes	0
CYP4F11-201 ENSP00000481243 ENST00000620614	F8W978 [Direct mapping] Phylloquinone omega-hydroxylase CYP4F11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	454 aa 52.2 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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