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TLN2

GENERAL INFORMATION

Gene name

 TLN2

Gene description

 Talin 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (cerebral cortex, kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, including in kidney and CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB017194
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), breast cancer (favourable) and stomach cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
CAB017194

GENE INFORMATION

Gene name

 TLN2 (HGNC Symbol)

Synonyms

 ILWEQ, KIAA0320

Description

 Talin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q22.2

Chromosome location (bp)

 62390526 - 62844631

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171914 (version 83.38)

Entrez gene

 83660

UniProt

 Q9Y4G6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4G6

Antibodypedia

 TLN2 antibodies

PROTEIN BROWSER
TLN2-001
TLN2-003
TLN2-004
TLN2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLN2-001
ENSP00000453508
ENST00000561311
Q9Y4G6 [Direct mapping]
Talin-2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005158 [insulin receptor binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005916 [fascia adherens]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007043 [cell-cell junction assembly]
GO:0007155 [cell adhesion]
GO:0015629 [actin cytoskeleton]
GO:0045202 [synapse]
GO:0051015 [actin filament binding]
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 2542 aa
271.6 kDa 		No 0
TLN2-003
ENSP00000453812
ENST00000472902
H0YN01 [Direct mapping]
Talin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007155 [cell adhesion]
GO:0051015 [actin filament binding]
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 330 aa
35.3 kDa 		No 0
TLN2-004
ENSP00000453730
ENST00000494733
H0YMT1 [Direct mapping]
Talin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0007155 [cell adhesion]
GO:0051015 [actin filament binding]
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 1471 aa
154.7 kDa 		No 0
TLN2-201
ENSP00000303476
ENST00000306829
Q9Y4G6 [Direct mapping]
Talin-2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005158 [insulin receptor binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007043 [cell-cell junction assembly]
GO:0007155 [cell adhesion]
GO:0015629 [actin cytoskeleton]
GO:0045202 [synapse]
GO:0051015 [actin filament binding]
Show all
 2542 aa
271.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.