Expression of CYP4F22 in cancer - Summary - The Human Protein Atlas

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CYP4F22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CYP4F22
Gene description	Cytochrome P450, family 4, subfamily F, polypeptide 22
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, head and neck cancer, liver cancer, melanoma, urothelial cancer)
HPA (cell line):	Cell line enhanced (MCF7)
HPA (normal tissue):	Tissue enhanced (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA058960
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, head and neck cancer, liver cancer, melanoma, urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058960

GENE INFORMATION
Gene name	CYP4F22 (HGNC Symbol)
Synonyms	FLJ39501
Description	Cytochrome P450, family 4, subfamily F, polypeptide 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	15508493 - 15552317
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171954 (version 83.38)
Entrez gene	126410
UniProt	Q6NT55 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6NT55
Antibodypedia	CYP4F22 antibodies

PROTEIN BROWSER

CYP4F22-002	CYP4F22-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP4F22-002 ENSP00000269703 ENST00000269703	Q6NT55 [Direct mapping] Cytochrome P450 4F22 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006690 [icosanoid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	531 aa 62 kDa	No	2
CYP4F22-201 ENSP00000469866 ENST00000601005	Q6NT55 [Direct mapping] Cytochrome P450 4F22 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006690 [icosanoid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	531 aa 62 kDa	No	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.