Expression of SYNPO in cancer - Summary

GENERAL INFORMATION
Gene name	SYNPO
Gene description	Synaptopodin
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BEWO, TIME, U-87 MG)
HPA (normal tissue):	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including glomeruli in kidney, skeletal muscle and CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 3 antibodies. HPA034631 , CAB033265 , CAB037325
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA034631	CAB033265	CAB037325

GENE INFORMATION
Gene name	SYNPO (HGNC Symbol)
Synonyms	KIAA1029
Description	Synaptopodin (HGNC Symbol)
Entrez gene summary	Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).[supplied by OMIM, Mar 2008]
Chromosome	5
Cytoband	q33.1
Chromosome location (bp)	150601080 - 150659220
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171992 (version 83.38)
Entrez gene	11346
UniProt	Q8N3V7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N3V7
Antibodypedia	SYNPO antibodies

PROTEIN BROWSER

SYNPO-001	SYNPO-002	SYNPO-003	SYNPO-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYNPO-001 ENSP00000302139 ENST00000307662	Q8N3V7 [Direct mapping] Synaptopodin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0014069 [postsynaptic density] GO:0015629 [actin cytoskeleton] GO:0032233 [positive regulation of actin filament bundle assembly] GO:0043197 [dendritic spine] GO:0043204 [perikaryon] GO:0045211 [postsynaptic membrane] GO:0051492 [regulation of stress fiber assembly] Show all	903 aa 96.4 kDa	No	0
SYNPO-002 ENSP00000377789 ENST00000394243	Q8N3V7 [Direct mapping] Synaptopodin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0014069 [postsynaptic density] GO:0015629 [actin cytoskeleton] GO:0032233 [positive regulation of actin filament bundle assembly] GO:0043197 [dendritic spine] GO:0043204 [perikaryon] GO:0045211 [postsynaptic membrane] GO:0051492 [regulation of stress fiber assembly] Show all	929 aa 99.5 kDa	No	0
SYNPO-003 ENSP00000428378 ENST00000522122	Q8N3V7 [Direct mapping] Synaptopodin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0014069 [postsynaptic density] GO:0015629 [actin cytoskeleton] GO:0032233 [positive regulation of actin filament bundle assembly] GO:0043197 [dendritic spine] GO:0043204 [perikaryon] GO:0045211 [postsynaptic membrane] GO:0051492 [regulation of stress fiber assembly] Show all	929 aa 99.5 kDa	No	0
SYNPO-004 ENSP00000429268 ENST00000519664	Q8N3V7 [Direct mapping] Synaptopodin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0014069 [postsynaptic density] GO:0015629 [actin cytoskeleton] GO:0032233 [positive regulation of actin filament bundle assembly] GO:0043197 [dendritic spine] GO:0043204 [perikaryon] GO:0045211 [postsynaptic membrane] GO:0051492 [regulation of stress fiber assembly] Show all	685 aa 73.7 kDa	No	0