Expression of ZNF554 in cancer - Summary - The Human Protein Atlas

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ZNF554

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF554
Gene description	Zinc finger protein 554
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA060247
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (favourable), urothelial cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Urothelial cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA060247

Cancer	Cancer staining
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Moderate to strong cytoplasmic and/or nuclear immunoreactivity was observed in several melanomas, squamous cell carcinomas, urothelial and colorectal cancers along with few ovarian, renal, stomach and prostate cancers. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION
Gene name	ZNF554 (HGNC Symbol)
Synonyms	FLJ34817
Description	Zinc finger protein 554 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2819874 - 2835773
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172006 (version 83.38)
Entrez gene	115196
UniProt	Q86TJ5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86TJ5
Antibodypedia	ZNF554 antibodies

PROTEIN BROWSER

ZNF554-001	ZNF554-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF554-001 ENSP00000321132 ENST00000317243	Q86TJ5 [Direct mapping] Zinc finger protein 554 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	538 aa 60.6 kDa	No	0
ZNF554-004 ENSP00000467997 ENST00000591265	K7EQV8 [Direct mapping] Zinc finger protein 554 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	181 aa 19.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.