Expression of THOP1 in cancer - Summary - The Human Protein Atlas

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THOP1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	THOP1
Gene description	Thimet oligopeptidase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA035262 , CAB025497
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and stomach cancer (favourable).
Endometrial cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035262	CAB025497

GENE INFORMATION
Gene name	THOP1
Synonyms
Description	Thimet oligopeptidase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2785460 - 2815807
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172009 (version 83.38)
Entrez gene	7064
UniProt	P52888 (UniProt - Evidence at protein level)
neXtProt	NX_P52888
Antibodypedia	THOP1 antibodies

PROTEIN BROWSER

THOP1-001	THOP1-002	THOP1-004	THOP1-006	THOP1-010	THOP1-011	THOP1-012	THOP1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THOP1-001 ENSP00000304467 ENST00000307741	P52888 [Direct mapping] Thimet oligopeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0042277 [peptide binding] GO:0046872 [metal ion binding] Show all	689 aa 78.8 kDa	No	0
THOP1-002 ENSP00000467226 ENST00000586677	K7EP46 [Direct mapping] Thimet oligopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	568 aa 65.1 kDa	No	0
THOP1-004 ENSP00000378638 ENST00000395212	P52888 [Direct mapping] Thimet oligopeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	258 aa 28.9 kDa	No	0
THOP1-006 ENSP00000465855 ENST00000590970	K7EL02 [Direct mapping] Thimet oligopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	260 aa 29.1 kDa	No	0
THOP1-010 ENSP00000465545 ENST00000585338	K7EKB6 [Direct mapping] Thimet oligopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0046872 [metal ion binding] Show all	177 aa 20.7 kDa	No	0
THOP1-011 ENSP00000465895 ENST00000587401	K7EL32 [Direct mapping] Thimet oligopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	216 aa 24.3 kDa	No	0
THOP1-012 ENSP00000466653 ENST00000591363	K7EMU4 [Direct mapping] Thimet oligopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	204 aa 22.8 kDa	No	0
THOP1-013 ENSP00000464786 ENST00000587468	K7EIK4 [Direct mapping] Thimet oligopeptidase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	169 aa 19.1 kDa	No	0

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The Human Protein Atlas

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