Expression of LAMB2 in cancer - Summary

GENERAL INFORMATION
Gene name	LAMB2
Gene description	Laminin, beta 2 (laminin S)
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues, most abundant in extracellular matrix and vascular smooth muscles.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 3 antibodies. HPA001895 , CAB000053 , CAB078160
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA001895	CAB000053	CAB078160

GENE INFORMATION
Gene name	LAMB2 (HGNC Symbol)
Synonyms	LAMS
Description	Laminin, beta 2 (laminin S) (HGNC Symbol)
Entrez gene summary	Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49121114 - 49133118
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172037 (version 83.38)
Entrez gene	3913
UniProt	P55268 (UniProt - Evidence at protein level)
neXtProt	NX_P55268
Antibodypedia	LAMB2 antibodies

PROTEIN BROWSER

LAMB2-001	LAMB2-003	LAMB2-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAMB2-001 ENSP00000388325 ENST00000418109	P55268 [Direct mapping] Laminin subunit beta-2 A0A024R319 [Target identity:100%; Query identity:100%] Laminin, beta 2 (Laminin S), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000904 [cell morphogenesis involved in differentiation] GO:0005178 [integrin binding] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005605 [basal lamina] GO:0005608 [laminin-3 complex] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0007601 [visual perception] GO:0014002 [astrocyte development] GO:0014044 [Schwann cell development] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0031175 [neuron projection development] GO:0043256 [laminin complex] GO:0043260 [laminin-11 complex] GO:0045202 [synapse] GO:0048677 [axon extension involved in regeneration] GO:0050808 [synapse organization] GO:0060041 [retina development in camera-type eye] GO:0070062 [extracellular exosome] GO:0072249 [metanephric glomerular visceral epithelial cell development] GO:0072274 [metanephric glomerular basement membrane development] Show all	1798 aa 196 kDa	Yes	0
LAMB2-003 ENSP00000307156 ENST00000305544	P55268 [Direct mapping] Laminin subunit beta-2 A0A024R319 [Target identity:100%; Query identity:100%] Laminin, beta 2 (Laminin S), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005605 [basal lamina] GO:0005608 [laminin-3 complex] GO:0007155 [cell adhesion] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0043260 [laminin-11 complex] GO:0070062 [extracellular exosome] Show all	1798 aa 196 kDa	Yes	0
LAMB2-018 ENSP00000444751 ENST00000494831	F5H520 [Direct mapping] Laminin subunit beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 17.3 kDa	No	0