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QARS

GENERAL INFORMATION

Gene name

 QARS

Gene description

 Glutaminyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA036986 , HPA036987
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA036986
HPA036987

GENE INFORMATION

Gene name

 QARS

Synonyms

Description

 Glutaminyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 49095932 - 49105135

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172053 (version 83.38)

Entrez gene

 5859

UniProt

 P47897 (UniProt - Evidence at protein level)

neXtProt

 NX_P47897

Antibodypedia

 QARS antibodies

PROTEIN BROWSER
«
QARS-001
QARS-005
QARS-006
QARS-009
QARS-015
QARS-019
QARS-023
QARS-028
QARS-031
QARS-033
QARS-037
QARS-039
QARS-041
QARS-042
QARS-047
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
QARS-001
ENSP00000307567
ENST00000306125
P47897 [Direct mapping]
Glutamine--tRNA ligase
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
GO:0007420 [brain development]
GO:0010467 [gene expression]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 775 aa
87.8 kDa 		No 0
QARS-005
ENSP00000390015
ENST00000414533
P47897 [Direct mapping]
Glutamine--tRNA ligase
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
GO:0007420 [brain development]
GO:0010467 [gene expression]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 764 aa
86.6 kDa 		No 0
QARS-006
ENSP00000489011
ENST00000464962
B4DDN1 [Target identity:100%; Query identity:100%]
Glutaminyl-tRNA synthetase, isoform CRA_a; cDNA FLJ54487, highly similar to Glutaminyl-tRNA synthetase (EC 6.1.1.18)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 630 aa
71.7 kDa 		No 0
QARS-009
ENSP00000396326
ENST00000453392
H7C0R3 [Direct mapping]
Glutamine--tRNA ligase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 253 aa
28.6 kDa 		No 0
QARS-015
ENSP00000489462
ENST00000466179
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 91 aa
10.1 kDa 		No 0
QARS-019
ENSP00000489118
ENST00000634432
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 195 aa
22.7 kDa 		No 0
QARS-023
ENSP00000392850
ENST00000452739
C9J165 [Direct mapping]
Glutamine--tRNA ligase
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 339 aa
38.1 kDa 		No 0
QARS-028
ENSP00000489558
ENST00000635622
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006425 [glutaminyl-tRNA aminoacylation]
Show all
 68 aa
7.7 kDa 		No 0
QARS-031
ENSP00000489039
ENST00000634527
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006425 [glutaminyl-tRNA aminoacylation]
Show all
 96 aa
10.9 kDa 		No 0
QARS-033
ENSP00000489550
ENST00000635231
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
Show all
 183 aa
20.4 kDa 		No 0
QARS-037
ENSP00000488960
ENST00000635194
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
Show all
 187 aa
20.8 kDa 		No 0
QARS-039
ENSP00000489082
ENST00000634602
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 173 aa
19.1 kDa 		No 0
QARS-041
ENSP00000489365
ENST00000635541
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 173 aa
19.5 kDa 		No 0
QARS-042
ENSP00000489056
ENST00000635292
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
Show all
 191 aa
21.4 kDa 		No 1
QARS-047
ENSP00000489154
ENST00000635443
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004819 [glutamine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006425 [glutaminyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 342 aa
38.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.