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This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Q9UDY8 [Direct mapping] Mucosa-associated lymphoid tissue lymphoma translocation protein 1
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Enzymes Peptidases Cysteine-type peptidases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001923 [B-1 B cell differentiation] GO:0002020 [protease binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002237 [response to molecule of bacterial origin] GO:0002726 [positive regulation of T cell cytokine production] GO:0004197 [cysteine-type endopeptidase activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006952 [defense response] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0008233 [peptidase activity] GO:0009620 [response to fungus] GO:0016567 [protein ubiquitination] GO:0019209 [kinase activator activity] GO:0031398 [positive regulation of protein ubiquitination] GO:0032449 [CBM complex] GO:0032743 [positive regulation of interleukin-2 production] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042098 [T cell proliferation] GO:0042113 [B cell activation] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0043621 [protein self-association] GO:0045087 [innate immune response] GO:0048471 [perinuclear region of cytoplasm] GO:0050852 [T cell receptor signaling pathway] GO:0050856 [regulation of T cell receptor signaling pathway] GO:0050870 [positive regulation of T cell activation] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051168 [nuclear export] GO:0051259 [protein oligomerization]
Q9UDY8 [Direct mapping] Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Show all
Enzymes Peptidases Cysteine-type peptidases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
K7EP42 [Direct mapping] Mucosa-associated lymphoid tissue lymphoma translocation protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)