Tissue expression of PRL - Summary - The Human Protein Atlas

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PRL

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PRL
Gene description	Prolactin
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (endometrium, placenta)
GTEx:	Tissue enriched (pituitary gland)
FANTOM5:	Tissue enriched (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in pituitary gland.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with external characterization data and GTEx RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA042416 , HPA062017 , CAB023353
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Pituitary gland

N/A

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Pituitary gland

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (endometrium, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION
Gene name	PRL
Synonyms
Description	Prolactin (HGNC Symbol)
Entrez gene summary	This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Chromosome	6
Cytoband	p22.3
Chromosome location (bp)	22287244 - 22297501
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172179 (version 83.38)
Entrez gene	5617
UniProt	P01236 (UniProt - Evidence at protein level)
neXtProt	NX_P01236
Antibodypedia	PRL antibodies

PROTEIN BROWSER

PRL-001	PRL-201	PRL-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRL-001 ENSP00000302150 ENST00000306482	P01236 [Direct mapping] Prolactin Q5THQ0 [Target identity:100%; Query identity:100%] Prolactin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005148 [prolactin receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0007166 [cell surface receptor signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0008283 [cell proliferation] GO:0040014 [regulation of multicellular organism growth] GO:0044267 [cellular protein metabolic process] GO:0046427 [positive regulation of JAK-STAT cascade] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	227 aa 25.9 kDa	Yes	0
PRL-201 ENSP00000478566 ENST00000615510	A6XMH3 [Direct mapping] Prolactin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	196 aa 22.6 kDa	Yes	0
PRL-202 ENSP00000480195 ENST00000617911	Q5I0G2 [Direct mapping] Prolactin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	228 aa 25.9 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.