Tissue expression of CXCR6 - Summary - The Human Protein Atlas

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CXCR6

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CXCR6
Gene description	Chemokine (C-X-C motif) receptor 6
Protein class	CD markers G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA047591
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	CXCR6 (HGNC Symbol)
Synonyms	BONZO, CD186, STRL33, TYMSTR
Description	Chemokine (C-X-C motif) receptor 6 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	45940933 - 45948353
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172215 (version 83.38)
Entrez gene	10663
UniProt	O00574 (UniProt - Evidence at transcript level)
neXtProt	NX_O00574
Antibodypedia	CXCR6 antibodies

PROTEIN BROWSER

CXCR6-001	CXCR6-002	CXCR6-003	CXCR6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXCR6-001 ENSP00000304414 ENST00000304552	O00574 [Direct mapping] C-X-C chemokine receptor type 6 A0N0N3 [Target identity:100%; Query identity:100%] Chemokine (C-X-C motif) receptor 6; cDNA, FLJ94355, Homo sapiens chemokine (C-X-C motif) receptor 6 (CXCR6), mRNA Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0019079 [viral genome replication] GO:0070098 [chemokine-mediated signaling pathway] Show all	342 aa 39.3 kDa	No	7
CXCR6-002 ENSP00000396218 ENST00000438735	O00574 [Direct mapping] C-X-C chemokine receptor type 6 A0N0N3 [Target identity:100%; Query identity:100%] Chemokine (C-X-C motif) receptor 6; cDNA, FLJ94355, Homo sapiens chemokine (C-X-C motif) receptor 6 (CXCR6), mRNA Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0019079 [viral genome replication] GO:0070098 [chemokine-mediated signaling pathway] Show all	342 aa 39.3 kDa	No	7
CXCR6-003 ENSP00000396886 ENST00000457814	O00574 [Direct mapping] C-X-C chemokine receptor type 6 A0N0N3 [Target identity:100%; Query identity:100%] Chemokine (C-X-C motif) receptor 6; cDNA, FLJ94355, Homo sapiens chemokine (C-X-C motif) receptor 6 (CXCR6), mRNA Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0019079 [viral genome replication] GO:0070098 [chemokine-mediated signaling pathway] Show all	342 aa 39.3 kDa	No	7
CXCR6-004 ENSP00000395704 ENST00000458629	O00574 [Direct mapping] C-X-C chemokine receptor type 6 A0N0N3 [Target identity:100%; Query identity:100%] Chemokine (C-X-C motif) receptor 6; cDNA, FLJ94355, Homo sapiens chemokine (C-X-C motif) receptor 6 (CXCR6), mRNA Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0019079 [viral genome replication] GO:0019958 [C-X-C chemokine binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	342 aa 39.3 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.