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Moderate to strong nuclear immunoreactivity was observed in most cancer tissues. Lymphomas, prostate and renal cancers were generally negative.
GENE INFORMATION
Gene name
CEBPB (HGNC Symbol)
Synonyms
C/EBP-beta, CRP2, IL6DBP, LAP, NFIL6, TCF5
Description
CCAAT/enhancer binding protein (C/EBP), beta (HGNC Symbol)
Entrez gene summary
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]