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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AZU1
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AZU1

Gene description

Azurocidin 1

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (THP-1)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subsets of hematopoietic cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA055851
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA055851

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few urothelial cancers showed moderate cytoplasmic immunoreactivity. Few colorectal, breast and prostate cancers were weakly stained. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

AZU1 (HGNC Symbol)

Synonyms

AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC

Description

Azurocidin 1 (HGNC Symbol)

Entrez gene summary

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

825097 - 832018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172232 (version 83.38)

Entrez gene

566

UniProt

P20160 (UniProt - Evidence at protein level)

neXtProt

NX_P20160

Antibodypedia

AZU1 antibodies

PROTEIN BROWSER

AZU1-001
AZU1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AZU1-001
ENSP00000233997
ENST00000233997
P20160 [Direct mapping]
Azurocidin
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Enzymes
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001774 [microglial cell activation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0008347 [glial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0015643 [toxic substance binding]
GO:0016485 [protein processing]
GO:0019730 [antimicrobial humoral response]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0042117 [monocyte activation]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0042582 [azurophil granule]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0045123 [cellular extravasation]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045785 [positive regulation of cell adhesion]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048246 [macrophage chemotaxis]
GO:0050725 [positive regulation of interleukin-1 beta biosynthetic process]
GO:0050754 [positive regulation of fractalkine biosynthetic process]
GO:0050766 [positive regulation of phagocytosis]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050930 [induction of positive chemotaxis]
GO:0051607 [defense response to virus]
GO:0060326 [cell chemotaxis]
GO:0070062 [extracellular exosome]
GO:0070528 [protein kinase C signaling]
Show all
251 aa
26.9 kDa
Yes 0
AZU1-002
ENSP00000481172
ENST00000592205
A0A087WXP0 [Direct mapping]
Azurocidin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006955 [immune response]
GO:0016485 [protein processing]
Show all
150 aa
16.4 kDa
No 0

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