Cell atlas - PAIP1 - The Human Protein Atlas

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PAIP1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PAIP1
Gene description	Poly(A) binding protein interacting protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA076187
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA076187	SiHa	Plasma membrane
	HPA076187	SiHa	Cytosol
	HPA076187	U-2 OS	Plasma membrane	Intensity
	HPA076187	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PAIP1
Synonyms
Description	Poly(A) binding protein interacting protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	p12
Chromosome location (bp)	43526267 - 43557758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172239 (version 83.38)
Entrez gene	10605
UniProt	Q9H074 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H074
Antibodypedia	PAIP1 antibodies

PROTEIN BROWSER

PAIP1-001	PAIP1-002	PAIP1-003	PAIP1-004	PAIP1-006	PAIP1-007	PAIP1-008	PAIP1-009	PAIP1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAIP1-001 ENSP00000302768 ENST00000306846	Q9H074 [Direct mapping] Polyadenylate-binding protein-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006413 [translational initiation] GO:0008494 [translation activator activity] GO:0010467 [gene expression] GO:0045727 [positive regulation of translation] GO:0048255 [mRNA stabilization] Show all	479 aa 53.5 kDa	No	0
PAIP1-002 ENSP00000339622 ENST00000338972	Q9H074 [Direct mapping] Polyadenylate-binding protein-interacting protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006413 [translational initiation] GO:0008494 [translation activator activity] GO:0010467 [gene expression] GO:0045727 [positive regulation of translation] GO:0048255 [mRNA stabilization] Show all	367 aa 42 kDa	No	0
PAIP1-003 ENSP00000387729 ENST00000436644	Q9H074 [Direct mapping] Polyadenylate-binding protein-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006413 [translational initiation] GO:0008494 [translation activator activity] GO:0010467 [gene expression] GO:0045727 [positive regulation of translation] GO:0048255 [mRNA stabilization] Show all	400 aa 45.6 kDa	No	0
PAIP1-004 ENSP00000425084 ENST00000514514	D6REB4 [Direct mapping] Polyadenylate-binding protein-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] Show all	351 aa 39.9 kDa	No	0
PAIP1-006 ENSP00000425675 ENST00000511321	D6RJF2 [Direct mapping] Polyadenylate-binding protein-interacting protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] Show all	200 aa 22.6 kDa	No	0
PAIP1-007 ENSP00000426089 ENST00000514816	H0YA44 [Direct mapping] Polyadenylate-binding protein-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.6 kDa	No	0
PAIP1-008 ENSP00000425736 ENST00000508537	D6RJ02 [Direct mapping] Polyadenylate-binding protein-interacting protein 1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] Show all	168 aa 19.1 kDa	No	0
PAIP1-009 ENSP00000427410 ENST00000504075		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.1 kDa	No	0
PAIP1-010 ENSP00000425406 ENST00000515338	D6RD97 [Direct mapping] Polyadenylate-binding protein-interacting protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 10.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.