Expression of DPAGT1 in cancer - Summary - The Human Protein Atlas

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DPAGT1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPAGT1
Gene description	Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, often in a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA053878
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053878

GENE INFORMATION
Gene name	DPAGT1 (HGNC Symbol)
Synonyms	ALG7, CDG-Ij, D11S366, DGPT, DPAGT, DPAGT2, GPT
Description	Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	119096503 - 119108331
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172269 (version 83.38)
Entrez gene	1798
UniProt	Q9H3H5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H3H5
Antibodypedia	DPAGT1 antibodies

PROTEIN BROWSER

DPAGT1-001	DPAGT1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPAGT1-001 ENSP00000346142 ENST00000354202	Q9H3H5 [Direct mapping] UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase A0A024R3H8 [Target identity:100%; Query identity:100%] Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003975 [UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006047 [UDP-N-acetylglucosamine metabolic process] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008963 [phospho-N-acetylmuramoyl-pentapeptide-transferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019408 [dolichol biosynthetic process] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051259 [protein oligomerization] Show all	408 aa 46.1 kDa	No	>9
DPAGT1-002 ENSP00000386597 ENST00000409993	Q9H3H5 [Direct mapping] UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase A0A024R3H8 [Target identity:100%; Query identity:100%] Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003975 [UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006047 [UDP-N-acetylglucosamine metabolic process] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008963 [phospho-N-acetylmuramoyl-pentapeptide-transferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019348 [dolichol metabolic process] GO:0019408 [dolichol biosynthetic process] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051259 [protein oligomerization] Show all	408 aa 46.1 kDa	No	>9

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The Human Protein Atlas

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