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CERS6

GENERAL INFORMATION

Gene name

 CERS6

Gene description

 Ceramide synthase 6

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044683
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA044683

GENE INFORMATION

Gene name

 CERS6 (HGNC Symbol)

Synonyms

 LASS6

Description

 Ceramide synthase 6 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q24.3

Chromosome location (bp)

 168455862 - 168775137

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172292 (version 83.38)

Entrez gene

 253782

UniProt

 Q6ZMG9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZMG9

Antibodypedia

 CERS6 antibodies

PROTEIN BROWSER
CERS6-001
CERS6-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CERS6-001
ENSP00000306579
ENST00000305747
Q6ZMG9 [Direct mapping]
Ceramide synthase 6
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006665 [sphingolipid metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030148 [sphingolipid biosynthetic process]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0046513 [ceramide biosynthetic process]
GO:0050291 [sphingosine N-acyltransferase activity]
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 384 aa
44.9 kDa 		No 7
CERS6-002
ENSP00000376453
ENST00000392687
Q6ZMG9 [Direct mapping]
Ceramide synthase 6
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006665 [sphingolipid metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030148 [sphingolipid biosynthetic process]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0046513 [ceramide biosynthetic process]
GO:0050291 [sphingosine N-acyltransferase activity]
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 392 aa
45.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.