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TP53RK

GENERAL INFORMATION

Gene name

 TP53RK

Gene description

 TP53 regulating kinase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA015837 , CAB004688
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA015837
CAB004688

GENE INFORMATION

Gene name

 TP53RK (HGNC Symbol)

Synonyms

 BUD32, C20orf64, dJ101A2.2, Nori-2p, prpk

Description

 TP53 regulating kinase (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 46684365 - 46689779

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172315 (version 83.38)

Entrez gene

 112858

UniProt

 Q96S44 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96S44

Antibodypedia

 TP53RK antibodies

PROTEIN BROWSER
TP53RK-001
TP53RK-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TP53RK-001
ENSP00000361186
ENST00000372114
Q96S44 [Direct mapping]
TP53-regulating kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000408 [EKC/KEOPS complex]
GO:0002039 [p53 binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006400 [tRNA modification]
GO:0006468 [protein phosphorylation]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0016787 [hydrolase activity]
GO:0070525 [tRNA threonylcarbamoyladenosine metabolic process]
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 253 aa
28.2 kDa 		No 0
TP53RK-002
ENSP00000361174
ENST00000372102
Q5JZ02 [Direct mapping]
TP53-regulating kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000408 [EKC/KEOPS complex]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0070525 [tRNA threonylcarbamoyladenosine metabolic process]
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 121 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.