Expression of CLEC12A in cancer - Summary

GENERAL INFORMATION
Gene name	CLEC12A
Gene description	C-type lectin domain family 12, member A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (HL-60, U-937)
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in bone marrow, spleen and a subset of inflammatory cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA048515
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048515

GENE INFORMATION
Gene name	CLEC12A (HGNC Symbol)
Synonyms	CD371, CLL-1, DCAL-2, MICL
Description	C-type lectin domain family 12, member A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	9951316 - 9995694
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172322 (version 83.38)
Entrez gene	160364
UniProt	Q5QGZ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5QGZ9
Antibodypedia	CLEC12A antibodies

PROTEIN BROWSER

CLEC12A-001	CLEC12A-002	CLEC12A-003	CLEC12A-006	CLEC12A-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC12A-001 ENSP00000302804 ENST00000304361	Q5QGZ9 [Direct mapping] C-type lectin domain family 12 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	265 aa 30.8 kDa	No	1
CLEC12A-002 ENSP00000405244 ENST00000434319	Q5QGZ9 [Direct mapping] C-type lectin domain family 12 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	213 aa 24.4 kDa	No	1
CLEC12A-003 ENSP00000345448 ENST00000350667	Q5QGZ9 [Direct mapping] C-type lectin domain family 12 member A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	232 aa 27.3 kDa	No	0
CLEC12A-006 ENSP00000379764 ENST00000396507	A8MVL9 [Direct mapping] C-type lectin domain family 12 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	165 aa 19 kDa	No	1
CLEC12A-007 ENSP00000347916 ENST00000355690	Q5QGZ9 [Direct mapping] C-type lectin domain family 12 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	275 aa 32 kDa	No	1