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BPGM

GENERAL INFORMATION

Gene name

 BPGM

Gene description

 2,3-bisphosphoglycerate mutase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective staining in placental trophoblasts and ovarian follicle cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA016493 , HPA028735
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016493
HPA028735

GENE INFORMATION

Gene name

 BPGM

Synonyms

Description

 2,3-bisphosphoglycerate mutase (HGNC Symbol)

Entrez gene summary

 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 134646808 - 134679813

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172331 (version 83.38)

Entrez gene

 669

UniProt

 P07738 (UniProt - Evidence at protein level)

neXtProt

 NX_P07738

Antibodypedia

 BPGM antibodies

PROTEIN BROWSER
BPGM-001
BPGM-003
BPGM-004
BPGM-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BPGM-001
ENSP00000342032
ENST00000344924
P07738 [Direct mapping]
Bisphosphoglycerate mutase
A0A024R782 [Target identity:100%; Query identity:100%]
2,3-bisphosphoglycerate mutase, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
   Isomerase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004082 [bisphosphoglycerate mutase activity]
GO:0004083 [bisphosphoglycerate 2-phosphatase activity]
GO:0004619 [phosphoglycerate mutase activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0007585 [respiratory gaseous exchange]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0043456 [regulation of pentose-phosphate shunt]
GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity]
GO:0070062 [extracellular exosome]
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 259 aa
30 kDa 		No 0
BPGM-003
ENSP00000399838
ENST00000418040
P07738 [Direct mapping]
Bisphosphoglycerate mutase
A0A024R782 [Target identity:100%; Query identity:100%]
2,3-bisphosphoglycerate mutase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Isomerase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004082 [bisphosphoglycerate mutase activity]
GO:0004083 [bisphosphoglycerate 2-phosphatase activity]
GO:0004619 [phosphoglycerate mutase activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0007585 [respiratory gaseous exchange]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0043456 [regulation of pentose-phosphate shunt]
GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity]
GO:0070062 [extracellular exosome]
Show all
 259 aa
30 kDa 		No 0
BPGM-004
ENSP00000376840
ENST00000393132
P07738 [Direct mapping]
Bisphosphoglycerate mutase
A0A024R782 [Target identity:100%; Query identity:100%]
2,3-bisphosphoglycerate mutase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Isomerase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004082 [bisphosphoglycerate mutase activity]
GO:0004083 [bisphosphoglycerate 2-phosphatase activity]
GO:0004619 [phosphoglycerate mutase activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0007585 [respiratory gaseous exchange]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0043456 [regulation of pentose-phosphate shunt]
GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity]
GO:0070062 [extracellular exosome]
Show all
 259 aa
30 kDa 		No 0
BPGM-005
ENSP00000403050
ENST00000443095
C9JH23 [Direct mapping]
Phosphoglycerate mutase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004619 [phosphoglycerate mutase activity]
GO:0006096 [glycolytic process]
GO:0008152 [metabolic process]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
Show all
 78 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.