Expression of ALG14 in cancer - Summary - The Human Protein Atlas

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ALG14

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ALG14
Gene description	ALG14, UDP-N-acetylglucosaminyltransferase subunit
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, mainly in vessels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA031829
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031829

GENE INFORMATION
Gene name	ALG14 (HGNC Symbol)
Synonyms	MGC19780
Description	ALG14, UDP-N-acetylglucosaminyltransferase subunit (HGNC Symbol)
Entrez gene summary	This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Chromosome	1
Cytoband	p21.3
Chromosome location (bp)	94974407 - 95072945
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172339 (version 83.38)
Entrez gene	199857
UniProt	Q96F25 (UniProt - Evidence at protein level)
neXtProt	NX_Q96F25
Antibodypedia	ALG14 antibodies

PROTEIN BROWSER

ALG14-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG14-001 ENSP00000359224 ENST00000370205	Q96F25 [Direct mapping] UDP-N-acetylglucosamine transferase subunit ALG14 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004577 [N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043495 [protein anchor] GO:0043541 [UDP-N-acetylglucosamine transferase complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	216 aa 24.2 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.