Expression of GNG12 in cancer - Summary

GENERAL INFORMATION
Gene name	GNG12
Gene description	Guanine nucleotide binding protein (G protein), gamma 12
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several tissues, including intestine and fallopian tube.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA057790 , HPA062208
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA057790	HPA062208

GENE INFORMATION
Gene name	GNG12
Synonyms
Description	Guanine nucleotide binding protein (G protein), gamma 12 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	67701466 - 67833467
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172380 (version 83.38)
Entrez gene	55970
UniProt	Q9UBI6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBI6
Antibodypedia	GNG12 antibodies

PROTEIN BROWSER

GNG12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNG12-001 ENSP00000360021 ENST00000370982	Q9UBI6 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005834 [heterotrimeric G-protein complex] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0021987 [cerebral cortex development] GO:0030165 [PDZ domain binding] GO:0032496 [response to lipopolysaccharide] GO:0042301 [phosphate ion binding] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	72 aa 8 kDa	No	0