Expression of EFCAB3 in cancer - Summary - The Human Protein Atlas

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EFCAB3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EFCAB3
Gene description	EF-hand calcium binding domain 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA046862
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046862

GENE INFORMATION
Gene name	EFCAB3 (HGNC Symbol)
Synonyms	FLJ25818
Description	EF-hand calcium binding domain 3 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q23.2
Chromosome location (bp)	62370218 - 62416476
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172421 (version 83.38)
Entrez gene	146779
UniProt	Q8N7B9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N7B9
Antibodypedia	EFCAB3 antibodies

PROTEIN BROWSER

EFCAB3-001	EFCAB3-002	EFCAB3-003	EFCAB3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EFCAB3-001 ENSP00000302649 ENST00000305286	Q8N7B9 [Direct mapping] EF-hand calcium-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	438 aa 50.1 kDa	No	0
EFCAB3-002 ENSP00000403932 ENST00000450662	Q8N7B9 [Direct mapping] EF-hand calcium-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	490 aa 56 kDa	No	0
EFCAB3-003 ENSP00000429124 ENST00000520404	E5RJB7 [Direct mapping] EF-hand calcium-binding domain-containing protein 3 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	174 aa 19.7 kDa	No	0
EFCAB3-004 ENSP00000428626 ENST00000518576	E5RHB1 [Direct mapping] EF-hand calcium-binding domain-containing protein 3 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	162 aa 18.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.