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Weak to moderate cytoplasmic staining in the majority of cancer tissues. Single cases of liver, pancreatic, testicular cancers and lymphomas showed strong but diffuse granular cytoplasmic staining.
Cancer cells were in general negative. A few cases of ovarian, testicular and liver cancers showed moderate cytoplasmic and/or membranous positivity.
GENE INFORMATION
Gene name
MANEA (HGNC Symbol)
Synonyms
FLJ12838, mandaselin
Description
Mannosidase, endo-alpha (HGNC Symbol)
Entrez gene summary
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]