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FIBP

GENERAL INFORMATION

Gene name

 FIBP

Gene description

 Fibroblast growth factor (acidic) intracellular binding protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA011729
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FIBP (HGNC Symbol)

Synonyms

 FGFIBP

Description

 Fibroblast growth factor (acidic) intracellular binding protein (HGNC Symbol)

Entrez gene summary

 Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65883741 - 65888539

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172500 (version 83.38)

Entrez gene

 9158

UniProt

 O43427 (UniProt - Evidence at protein level)

neXtProt

 NX_O43427

Antibodypedia

 FIBP antibodies

PROTEIN BROWSER
FIBP-001
FIBP-002
FIBP-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FIBP-001
ENSP00000344572
ENST00000338369
O43427 [Direct mapping]
Acidic fibroblast growth factor intracellular-binding protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
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 364 aa
41.9 kDa 		No 0
FIBP-002
ENSP00000350124
ENST00000357519
O43427 [Direct mapping]
Acidic fibroblast growth factor intracellular-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
Show all
 357 aa
41.2 kDa 		No 0
FIBP-007
ENSP00000434043
ENST00000533045
E9PSD3 [Direct mapping]
Acidic fibroblast growth factor intracellular-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0017134 [fibroblast growth factor binding]
Show all
 348 aa
39.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.