Expression of CARNS1 in cancer - Summary - The Human Protein Atlas

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CARNS1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CARNS1
Gene description	Carnosine synthase 1
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, thyroid cancer)
HPA (cell line):	Cell line enriched (RPMI-8226)
HPA (normal tissue):	Group enriched (cerebral cortex, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038569
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038569

GENE INFORMATION
Gene name	CARNS1 (HGNC Symbol)
Synonyms	ATPGD1, KIAA1394
Description	Carnosine synthase 1 (HGNC Symbol)
Entrez gene summary	CARNS1 (EC 6.3.2.11), a member of the ATP-grasp family of ATPases, catalyzes the formation of carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine), which are found mainly in skeletal muscle and the central nervous system, respectively (Drozak et al., 2010 [PubMed 20097752]).[supplied by OMIM, Apr 2010]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	67414968 - 67425607
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172508 (version 83.38)
Entrez gene	57571
UniProt	A5YM72 (UniProt - Evidence at protein level)
neXtProt	NX_A5YM72
Antibodypedia	CARNS1 antibodies

PROTEIN BROWSER

CARNS1-001	CARNS1-002	CARNS1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARNS1-001 ENSP00000308268 ENST00000307823	A5YM72 [Direct mapping] Carnosine synthase 1 Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0016887 [ATPase activity] GO:0035499 [carnosine biosynthetic process] GO:0046872 [metal ion binding] GO:0047730 [carnosine synthase activity] Show all	827 aa 88.5 kDa	Yes	0
CARNS1-002 ENSP00000431670 ENST00000531040	A5YM72 [Direct mapping] Carnosine synthase 1 Show all	Enzymes ENZYME proteins Ligase Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0016887 [ATPase activity] GO:0035499 [carnosine biosynthetic process] GO:0046872 [metal ion binding] GO:0047730 [carnosine synthase activity] Show all	924 aa 98.7 kDa	No	0
CARNS1-201 ENSP00000389009 ENST00000445895	A5YM72 [Direct mapping] Carnosine synthase 1 Show all	Enzymes ENZYME proteins Ligase Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0016887 [ATPase activity] GO:0035499 [carnosine biosynthetic process] GO:0046872 [metal ion binding] GO:0047730 [carnosine synthase activity] Show all	950 aa 101.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.