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PPP1CA

GENERAL INFORMATION

Gene name

 PPP1CA

Gene description

 Protein phosphatase 1, catalytic subunit, alpha isozyme

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA046833 , CAB004545
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA046833
CAB004545

GENE INFORMATION

Gene name

 PPP1CA (HGNC Symbol)

Synonyms

 PP-1A, PP1A, PP1alpha, PPP1A

Description

 Protein phosphatase 1, catalytic subunit, alpha isozyme (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67398183 - 67421183

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172531 (version 83.38)

Entrez gene

 5499

UniProt

 P62136 (UniProt - Evidence at protein level)

neXtProt

 NX_P62136

Antibodypedia

 PPP1CA antibodies

PROTEIN BROWSER
PPP1CA-001
PPP1CA-002
PPP1CA-006
PPP1CA-007
PPP1CA-010
PPP1CA-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1CA-001
ENSP00000365936
ENST00000376745
P62136 [Direct mapping]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005977 [glycogen metabolic process]
GO:0006470 [protein dephosphorylation]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0019433 [triglyceride catabolic process]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0036496 [regulation of translational initiation by eIF2 alpha dephosphorylation]
GO:0042752 [regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070688 [MLL5-L complex]
GO:0072357 [PTW/PP1 phosphatase complex]
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 330 aa
37.5 kDa 		No 0
PPP1CA-002
ENSP00000326031
ENST00000312989
P62136 [Direct mapping]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005977 [glycogen metabolic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0005981 [regulation of glycogen catabolic process]
GO:0006470 [protein dephosphorylation]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008157 [protein phosphatase 1 binding]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0019433 [triglyceride catabolic process]
GO:0030324 [lung development]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032403 [protein complex binding]
GO:0032922 [circadian regulation of gene expression]
GO:0036496 [regulation of translational initiation by eIF2 alpha dephosphorylation]
GO:0042587 [glycogen granule]
GO:0042752 [regulation of circadian rhythm]
GO:0043005 [neuron projection]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043025 [neuronal cell body]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070688 [MLL5-L complex]
GO:0072357 [PTW/PP1 phosphatase complex]
GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 341 aa
38.6 kDa 		No 0
PPP1CA-006
ENSP00000350974
ENST00000358239
P62136 [Direct mapping]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005977 [glycogen metabolic process]
GO:0006470 [protein dephosphorylation]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0019433 [triglyceride catabolic process]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0036496 [regulation of translational initiation by eIF2 alpha dephosphorylation]
GO:0042752 [regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070688 [MLL5-L complex]
GO:0072357 [PTW/PP1 phosphatase complex]
Show all
 286 aa
32.6 kDa 		No 0
PPP1CA-007
ENSP00000431146
ENST00000527663
E9PMD7 [Direct mapping]
Serine/threonine-protein phosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016787 [hydrolase activity]
Show all
 253 aa
28.9 kDa 		No 0
PPP1CA-010
ENSP00000438409
ENST00000542876
F5H037 [Direct mapping]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 180 aa
19.3 kDa 		Yes 0
PPP1CA-011
ENSP00000439568
ENST00000546202
F5H1L6 [Direct mapping]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 169 aa
18.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.