Fields »
ABOUT
HELP
BLOG
RASGRP1

GENERAL INFORMATION

Gene name

 RASGRP1

Gene description

 RAS guanyl releasing protein 1 (calcium and DAG-regulated)

Protein class

 Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, lymph node)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 RASGRP1 (HGNC Symbol)

Synonyms

 CalDAG-GEFII, RASGRP

Description

 RAS guanyl releasing protein 1 (calcium and DAG-regulated) (HGNC Symbol)

Entrez gene summary

 This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q14

Chromosome location (bp)

 38488103 - 38565575

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172575 (version 83.38)

Entrez gene

 10125

UniProt

 O95267 (UniProt - Evidence at protein level)

neXtProt

 NX_O95267

Antibodypedia

 RASGRP1 antibodies

PROTEIN BROWSER
RASGRP1-001
RASGRP1-002
RASGRP1-003
RASGRP1-005
RASGRP1-006
RASGRP1-007
RASGRP1-008
RASGRP1-009
RASGRP1-010
RASGRP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASGRP1-001
ENSP00000310244
ENST00000310803
O95267 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001786 [phosphatidylserine binding]
GO:0001816 [cytokine production]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008289 [lipid binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0019992 [diacylglycerol binding]
GO:0030168 [platelet activation]
GO:0031210 [phosphatidylcholine binding]
GO:0032252 [secretory granule localization]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032816 [positive regulation of natural killer cell activation]
GO:0032825 [positive regulation of natural killer cell differentiation]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042629 [mast cell granule]
GO:0042803 [protein homodimerization activity]
GO:0043303 [mast cell degranulation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0047496 [vesicle transport along microtubule]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090630 [activation of GTPase activity]
GO:1902715 [positive regulation of interferon-gamma secretion]
Show all
 797 aa
90.4 kDa 		No 0
RASGRP1-002
ENSP00000452859
ENST00000561180
H0YKM0 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 848 aa
95.9 kDa 		No 0
RASGRP1-003
ENSP00000452721
ENST00000559830
O95267 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001786 [phosphatidylserine binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008289 [lipid binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0019992 [diacylglycerol binding]
GO:0030168 [platelet activation]
GO:0031210 [phosphatidylcholine binding]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090630 [activation of GTPase activity]
GO:1902715 [positive regulation of interferon-gamma secretion]
Show all
 597 aa
68.2 kDa 		No 0
RASGRP1-005
ENSP00000388540
ENST00000450598
O95267 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001786 [phosphatidylserine binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008289 [lipid binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0019992 [diacylglycerol binding]
GO:0030168 [platelet activation]
GO:0031210 [phosphatidylcholine binding]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090630 [activation of GTPase activity]
GO:1902715 [positive regulation of interferon-gamma secretion]
Show all
 762 aa
86.6 kDa 		No 0
RASGRP1-006
ENSP00000454164
ENST00000558164
O95267 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001786 [phosphatidylserine binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008289 [lipid binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0019992 [diacylglycerol binding]
GO:0030168 [platelet activation]
GO:0031210 [phosphatidylcholine binding]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090630 [activation of GTPase activity]
GO:1902715 [positive regulation of interferon-gamma secretion]
Show all
 546 aa
62.7 kDa 		No 0
RASGRP1-007
ENSP00000453583
ENST00000558432
H0YMF3 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 811 aa
92 kDa 		No 0
RASGRP1-008
ENSP00000454005
ENST00000561117
H0YNG8 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0007265 [Ras protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 57 aa
6.2 kDa 		No 0
RASGRP1-009
ENSP00000452892
ENST00000560929
H0YKP8 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 32 aa
3.3 kDa 		No 0
RASGRP1-010
ENSP00000453905
ENST00000558418
H0YN83 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0007265 [Ras protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 96 aa
10.9 kDa 		No 0
RASGRP1-201
ENSP00000444762
ENST00000539159
F5H514 [Direct mapping]
RAS guanyl-releasing protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 797 aa
90.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.