We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most malignancies showed moderate to strong nuclear immunoreactivity. Several cases of endometrial, renal, pancreatic and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
RAD9A (HGNC Symbol)
Synonyms
RAD9
Description
RAD9 checkpoint clamp component A (HGNC Symbol)
Entrez gene summary
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]