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Cell line enhanced (BJ, BJ hTERT+, LHCN-M2, U-138 MG)
HPA (normal tissue):
Expressed in all
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression in several tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Most breast cancers displayed weak to moderate cytoplasmic positivity. Remaining malignancies were in general negative.
GENE INFORMATION
Gene name
EFEMP2 (HGNC Symbol)
Synonyms
FBLN4, UPH1
Description
EGF containing fibulin-like extracellular matrix protein 2 (HGNC Symbol)
Entrez gene summary
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]