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MOS

GENERAL INFORMATION

Gene name

 MOS

Gene description

 V-mos Moloney murine sarcoma viral oncogene homolog

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040424
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040424

GENE INFORMATION

Gene name

 MOS

Synonyms

Description

 V-mos Moloney murine sarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

 MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

Chromosome

 8

Cytoband

 q12.1

Chromosome location (bp)

 56112942 - 56113982

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172680 (version 83.38)

Entrez gene

 4342

UniProt

 P00540 (UniProt - Evidence at protein level)

neXtProt

 NX_P00540

Antibodypedia

 MOS antibodies

PROTEIN BROWSER
MOS-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MOS-001
ENSP00000310722
ENST00000311923
P00540 [Direct mapping]
Proto-oncogene serine/threonine-protein kinase mos
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted intracellular proteins
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GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000212 [meiotic spindle organization]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006468 [protein phosphorylation]
GO:0040020 [regulation of meiotic nuclear division]
GO:0046777 [protein autophosphorylation]
GO:0051296 [establishment of meiotic spindle orientation]
GO:1902103 [negative regulation of metaphase/anaphase transition of meiotic cell cycle]
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 346 aa
37.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.