Fields »
ABOUT
HELP
BLOG
MUS81

GENERAL INFORMATION

Gene name

 MUS81

Gene description

 MUS81 structure-specific endonuclease subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nucleolar expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA059530
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059530

GENE INFORMATION

Gene name

 MUS81 (HGNC Symbol)

Synonyms

 FLJ44872, SLX3

Description

 MUS81 structure-specific endonuclease subunit (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65857126 - 65867653

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172732 (version 83.38)

Entrez gene

 80198

UniProt

 Q96NY9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96NY9

Antibodypedia

 MUS81 antibodies

PROTEIN BROWSER
MUS81-001
MUS81-002
MUS81-007
MUS81-013
MUS81-014
MUS81-017
MUS81-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MUS81-001
ENSP00000307853
ENST00000308110
Q96NY9 [Direct mapping]
Crossover junction endonuclease MUS81
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000737 [DNA catabolic process, endonucleolytic]
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0036297 [interstrand cross-link repair]
GO:0046872 [metal ion binding]
GO:0048257 [3'-flap endonuclease activity]
GO:0072429 [response to intra-S DNA damage checkpoint signaling]
Show all
 551 aa
61.2 kDa 		No 0
MUS81-002
ENSP00000432287
ENST00000533035
E9PRI1 [Direct mapping]
Crossover junction endonuclease MUS81
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 476 aa
52.3 kDa 		No 0
MUS81-007
ENSP00000431979
ENST00000529857
E9PII7 [Direct mapping]
Crossover junction endonuclease MUS81
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 203 aa
22.5 kDa 		No 0
MUS81-013
ENSP00000431478
ENST00000525768
E9PL60 [Direct mapping]
Crossover junction endonuclease MUS81
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 135 aa
14.9 kDa 		No 0
MUS81-014
ENSP00000433809
ENST00000530111
H0YDK3 [Direct mapping]
Crossover junction endonuclease MUS81
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0006259 [DNA metabolic process]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 231 aa
24.7 kDa 		No 0
MUS81-017
ENSP00000434305
ENST00000529374
H0YDU2 [Direct mapping]
Crossover junction endonuclease MUS81
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0006259 [DNA metabolic process]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 411 aa
45.2 kDa 		No 0
MUS81-018
ENSP00000435277
ENST00000529742
H0YE94 [Direct mapping]
Crossover junction endonuclease MUS81
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006281 [DNA repair]
Show all
 63 aa
6.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.