Expression of PURG in cancer - Summary - The Human Protein Atlas

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PURG

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PURG
Gene description	Purine-rich element binding protein G
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (AF22, NTERA-2, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA047746
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047746

GENE INFORMATION
Gene name	PURG (HGNC Symbol)
Synonyms	PURG-A, PURG-B
Description	Purine-rich element binding protein G (HGNC Symbol)
Entrez gene summary	The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p12
Chromosome location (bp)	30995802 - 31033715
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172733 (version 83.38)
Entrez gene	29942
UniProt	Q9UJV8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UJV8
Antibodypedia	PURG antibodies

PROTEIN BROWSER

PURG-001	PURG-002	PURG-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PURG-001 ENSP00000345168 ENST00000339382	Q9UJV8 [Direct mapping] Purine-rich element-binding protein gamma Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0044822 [poly(A) RNA binding] Show all	322 aa 36.6 kDa	No	0
PURG-002 ENSP00000418721 ENST00000475541	Q9UJV8 [Direct mapping] Purine-rich element-binding protein gamma Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0044822 [poly(A) RNA binding] Show all	347 aa 39.6 kDa	No	0
PURG-003 ENSP00000466881 ENST00000523392	K7ENC1 [Direct mapping] Purine-rich element-binding protein gamma Show all	Predicted intracellular proteins Show all		163 aa 17.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.