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SSH3

GENERAL INFORMATION

Gene name

 SSH3

Gene description

 Slingshot protein phosphatase 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RT4)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA019949 , HPA019957
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA019949
HPA019957

GENE INFORMATION

Gene name

 SSH3 (HGNC Symbol)

Synonyms

 FLJ10928, FLJ20515

Description

 Slingshot protein phosphatase 3 (HGNC Symbol)

Entrez gene summary

 The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67303448 - 67312607

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172830 (version 83.38)

Entrez gene

 54961

UniProt

 Q8TE77 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TE77

Antibodypedia

 SSH3 antibodies

PROTEIN BROWSER
SSH3-001
SSH3-002
SSH3-004
SSH3-006
SSH3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSH3-001
ENSP00000312081
ENST00000308127
Q8TE77 [Direct mapping]
Protein phosphatase Slingshot homolog 3
A0A024R5J4 [Target identity:100%; Query identity:100%]
Slingshot homolog 3 (Drosophila), isoform CRA_f
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003779 [actin binding]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006470 [protein dephosphorylation]
GO:0008064 [regulation of actin polymerization or depolymerization]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0010591 [regulation of lamellipodium assembly]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050770 [regulation of axonogenesis]
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 659 aa
73 kDa 		No 0
SSH3-002
ENSP00000365948
ENST00000376757
Q8TE77 [Direct mapping]
Protein phosphatase Slingshot homolog 3
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003779 [actin binding]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006470 [protein dephosphorylation]
GO:0008064 [regulation of actin polymerization or depolymerization]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0010591 [regulation of lamellipodium assembly]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050770 [regulation of axonogenesis]
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 513 aa
57 kDa 		No 0
SSH3-004
ENSP00000433902
ENST00000527821
E9PIT5 [Direct mapping]
Protein phosphatase Slingshot homolog 3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003779 [actin binding]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0008064 [regulation of actin polymerization or depolymerization]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0010591 [regulation of lamellipodium assembly]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050770 [regulation of axonogenesis]
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 219 aa
24.6 kDa 		No 0
SSH3-006
ENSP00000480198
ENST00000532181
A0A087WWG1 [Direct mapping]
Protein phosphatase Slingshot homolog 3
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0008064 [regulation of actin polymerization or depolymerization]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0010591 [regulation of lamellipodium assembly]
GO:0050770 [regulation of axonogenesis]
Show all
 316 aa
36 kDa 		No 0
SSH3-011
ENSP00000310055
ENST00000308298
C9JUG3 [Direct mapping]
Protein phosphatase Slingshot homolog 3; Slingshot homolog 3 (Drosophila), isoform CRA_e
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0008064 [regulation of actin polymerization or depolymerization]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0010591 [regulation of lamellipodium assembly]
GO:0050770 [regulation of axonogenesis]
Show all
 394 aa
42.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.