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SP3

GENERAL INFORMATION

Gene name

 SP3

Gene description

 Sp3 transcription factor

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB004580
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
CAB004580

GENE INFORMATION

Gene name

 SP3 (HGNC Symbol)

Synonyms

 SPR-2

Description

 Sp3 transcription factor (HGNC Symbol)

Entrez gene summary

 This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 173906459 - 173965702

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172845 (version 83.38)

Entrez gene

 6670

UniProt

 Q02447 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02447

Antibodypedia

 SP3 antibodies

PROTEIN BROWSER
SP3-001
SP3-002
SP3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SP3-001
ENSP00000310301
ENST00000310015
Q02447 [Direct mapping]
Transcription factor Sp3
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001503 [ossification]
GO:0001701 [in utero embryonic development]
GO:0001779 [natural killer cell differentiation]
GO:0001829 [trophectodermal cell differentiation]
GO:0001889 [liver development]
GO:0001892 [embryonic placenta development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016605 [PML body]
GO:0017053 [transcriptional repressor complex]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030219 [megakaryocyte differentiation]
GO:0030224 [monocyte differentiation]
GO:0030324 [lung development]
GO:0030851 [granulocyte differentiation]
GO:0043353 [enucleate erythrocyte differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0048706 [embryonic skeletal system development]
GO:0060136 [embryonic process involved in female pregnancy]
GO:0060216 [definitive hemopoiesis]
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 781 aa
81.9 kDa 		No 0
SP3-002
ENSP00000413665
ENST00000416195
H0Y7L6 [Direct mapping]
Transcription factor Sp3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 738 aa
77.9 kDa 		No 0
SP3-003
ENSP00000406140
ENST00000418194
H0Y6K5 [Direct mapping]
Transcription factor Sp3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 713 aa
75.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.