Expression of DMXL1 in cancer - Summary - The Human Protein Atlas

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DMXL1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DMXL1
Gene description	Dmx-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA036431 , HPA036432
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036431	HPA036432

GENE INFORMATION
Gene name	DMXL1
Synonyms
Description	Dmx-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	5
Cytoband	q23.1
Chromosome location (bp)	119037772 - 119249138
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172869 (version 83.38)
Entrez gene	1657
UniProt	Q9Y485 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y485
Antibodypedia	DMXL1 antibodies

PROTEIN BROWSER

DMXL1-001	DMXL1-002	DMXL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DMXL1-001 ENSP00000309690 ENST00000311085	Q9Y485 [Direct mapping] DmX-like protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	3027 aa 337.8 kDa	No	0
DMXL1-002 ENSP00000427692 ENST00000503802	E7EMZ0 [Direct mapping] DmX-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	589 aa 66.1 kDa	No	0
DMXL1-201 ENSP00000439479 ENST00000539542	F5H269 [Direct mapping] DmX-like protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	3048 aa 340.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.