Expression of EGFL7 in cancer - Summary - The Human Protein Atlas

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EGFL7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EGFL7
Gene description	EGF-like-domain, multiple 7
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21, HUVEC TERT2, TIME)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. CAB020815
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and renal cancer (unfavourable).
Colorectal cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB020815

GENE INFORMATION
Gene name	EGFL7 (HGNC Symbol)
Synonyms	ZNEU1
Description	EGF-like-domain, multiple 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136658856 - 136672678
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172889 (version 83.38)
Entrez gene	51162
UniProt	Q9UHF1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHF1
Antibodypedia	EGFL7 antibodies

PROTEIN BROWSER

EGFL7-001	EGFL7-002	EGFL7-003	EGFL7-005	EGFL7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EGFL7-001 ENSP00000360764 ENST00000371699	Q9UHF1 [Direct mapping] Epidermal growth factor-like protein 7 A0A024R8F5 [Target identity:100%; Query identity:100%] EGF-like-domain, multiple 7, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001568 [blood vessel development] GO:0001570 [vasculogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0005112 [Notch binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0030336 [negative regulation of cell migration] GO:0031012 [extracellular matrix] GO:0045746 [negative regulation of Notch signaling pathway] Show all	273 aa 29.6 kDa	Yes	0
EGFL7-002 ENSP00000385639 ENST00000406555	Q9UHF1 [Direct mapping] Epidermal growth factor-like protein 7 A0A024R8F5 [Target identity:100%; Query identity:100%] EGF-like-domain, multiple 7, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001568 [blood vessel development] GO:0001570 [vasculogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0031012 [extracellular matrix] GO:0045746 [negative regulation of Notch signaling pathway] Show all	273 aa 29.6 kDa	Yes	0
EGFL7-003 ENSP00000360763 ENST00000371698	Q9UHF1 [Direct mapping] Epidermal growth factor-like protein 7 A0A024R8F5 [Target identity:100%; Query identity:100%] EGF-like-domain, multiple 7, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001568 [blood vessel development] GO:0001570 [vasculogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0031012 [extracellular matrix] GO:0045746 [negative regulation of Notch signaling pathway] Show all	273 aa 29.6 kDa	Yes	0
EGFL7-005 ENSP00000473338 ENST00000492862	R4GMT3 [Direct mapping] Epidermal growth factor-like protein 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	66 aa 7.4 kDa	Yes	0
EGFL7-201 ENSP00000307843 ENST00000308874	Q9UHF1 [Direct mapping] Epidermal growth factor-like protein 7 A0A024R8F5 [Target identity:100%; Query identity:100%] EGF-like-domain, multiple 7, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001568 [blood vessel development] GO:0001570 [vasculogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0031012 [extracellular matrix] GO:0045746 [negative regulation of Notch signaling pathway] Show all	273 aa 29.6 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.