Expression of NBEA in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NBEA
Gene description	Neurobeachin
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissues types, including cerebral cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA039730 , HPA040385
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA039730	HPA040385

GENE INFORMATION
Gene name	NBEA (HGNC Symbol)
Synonyms	BCL8B, FLJ10197, KIAA1544
Description	Neurobeachin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	34942287 - 35673022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172915 (version 83.38)
Entrez gene	26960
UniProt	Q8NFP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFP9
Antibodypedia	NBEA antibodies

PROTEIN BROWSER

NBEA-001	NBEA-003	NBEA-201	NBEA-202	NBEA-203	NBEA-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NBEA-001 ENSP00000369271 ENST00000379939	Q5T321 [Direct mapping] Neurobeachin; Neurobeachin, isoform CRA_e Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	2943 aa 327.5 kDa	No	1
NBEA-003 ENSP00000369254 ENST00000379922	Q8NFP9 [Direct mapping] Neurobeachin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	524 aa 58.8 kDa	No	0
NBEA-201 ENSP00000308534 ENST00000310336	F5GXV7 [Direct mapping] Neurobeachin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	2947 aa 328 kDa	No	1
NBEA-202 ENSP00000383295 ENST00000400445	Q8NFP9 [Direct mapping] Neurobeachin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008104 [protein localization] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] GO:0019901 [protein kinase binding] Show all	2946 aa 327.8 kDa	No	1
NBEA-203 ENSP00000440233 ENST00000537702	Q8NFP9 [Direct mapping] Neurobeachin A0A0A6YYC1 [Direct mapping] Neurobeachin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	739 aa 84 kDa	No	0
NBEA-204 ENSP00000486239 ENST00000629018	A0A0D9SF28 [Direct mapping] Neurobeachin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	2946 aa 327.9 kDa	No	1