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ADH6

GENERAL INFORMATION

Gene name

 ADH6

Gene description

 Alcohol dehydrogenase 6 (class V)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Group enriched (Hep G2, RPTEC TERT1)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ADH6 (HGNC Symbol)

Synonyms

 ADH-5

Description

 Alcohol dehydrogenase 6 (class V) (HGNC Symbol)

Entrez gene summary

 This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99202638 - 99219537

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172955 (version 83.38)

Entrez gene

 130

UniProt

 P28332 (UniProt - Evidence at protein level)

neXtProt

 NX_P28332

Antibodypedia

 ADH6 antibodies

PROTEIN BROWSER
ADH6-001
ADH6-002
ADH6-003
ADH6-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADH6-001
ENSP00000378359
ENST00000394899
A0A0A0MS56 [Direct mapping]
Alcohol dehydrogenase 6
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 375 aa
39.8 kDa 		No 0
ADH6-002
ENSP00000378358
ENST00000394897
Q8IUN7 [Direct mapping]
ADH6 protein; Alcohol dehydrogenase 6
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 295 aa
31.3 kDa 		No 0
ADH6-003
ENSP00000237653
ENST00000237653
P28332 [Direct mapping]
Alcohol dehydrogenase 6
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0005829 [cytosol]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 368 aa
39.1 kDa 		No 0
ADH6-008
ENSP00000426187
ENST00000508558
D6RH17 [Direct mapping]
Alcohol dehydrogenase 6
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 257 aa
26.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.