Expression of GXYLT2 in cancer - Summary - The Human Protein Atlas

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GXYLT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GXYLT2
Gene description	Glucoside xylosyltransferase 2
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (MOLT-4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA068429
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA068429

GENE INFORMATION
Gene name	GXYLT2 (HGNC Symbol)
Synonyms	GLT8D4
Description	Glucoside xylosyltransferase 2 (HGNC Symbol)
Entrez gene summary	GXYLT2 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]).[supplied by OMIM, Mar 2010]
Chromosome	3
Cytoband	p13
Chromosome location (bp)	72888073 - 72998138
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000172986 (version 83.38)
Entrez gene	727936
UniProt	A0PJZ3 (UniProt - Evidence at transcript level)
neXtProt	NX_A0PJZ3
Antibodypedia	GXYLT2 antibodies

PROTEIN BROWSER

GXYLT2-001	GXYLT2-002	GXYLT2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GXYLT2-001 ENSP00000374268 ENST00000389617	A0PJZ3 [Direct mapping] Glucoside xylosyltransferase 2 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0035252 [UDP-xylosyltransferase activity] Show all	443 aa 51.1 kDa	Yes	0
GXYLT2-002 ENSP00000417239 ENST00000498315	C9J3Q6 [Direct mapping] Glucoside xylosyltransferase 2 Show all	Predicted intracellular proteins Show all		102 aa 12.3 kDa	No	0
GXYLT2-003 ENSP00000420426 ENST00000491839	C9JND4 [Direct mapping] Glucoside xylosyltransferase 2 Show all	Predicted intracellular proteins Show all	GO:0016757 [transferase activity, transferring glycosyl groups] Show all	164 aa 19.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.