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Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Most malignant cells displayed weak to moderate cytoplasmic and/or membranous immunoreactivity. Several cases of malignant melanomas, hepatocellular carcinomas and pancreatic cancers were strongly stained. Malignant gliomas, lymphomas, prostate, cervical and endometrial cancers were generally negative.
GENE INFORMATION
Gene name
HPSE2 (HGNC Symbol)
Synonyms
HPA2, HPR2, UFS
Description
Heparanase 2 (inactive) (HGNC Symbol)
Entrez gene summary
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]