Expression of ARPP21 in cancer - Summary

GENERAL INFORMATION
Gene name	ARPP21
Gene description	CAMP-regulated phosphoprotein, 21kDa
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	22
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Group enriched (MOLT-4, REH, RH-30)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in the brain and skeletal muscles.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA017303
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA017303

GENE INFORMATION
Gene name	ARPP21 (HGNC Symbol)
Synonyms	ARPP-21, R3HDM3, TARPP
Description	CAMP-regulated phosphoprotein, 21kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Chromosome	3
Cytoband	p22.3
Chromosome location (bp)	35638945 - 35794496
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172995 (version 83.38)
Entrez gene	10777
UniProt	Q9UBL0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBL0
Antibodypedia	ARPP21 antibodies

PROTEIN BROWSER

ARPP21-001	ARPP21-002	ARPP21-003	ARPP21-004	ARPP21-005	ARPP21-006	ARPP21-008	ARPP21-009	ARPP21-012	ARPP21-013	ARPP21-015	ARPP21-016	ARPP21-017	ARPP21-018	ARPP21-021	ARPP21-022	ARPP21-023	ARPP21-024	ARPP21-025	ARPP21-027	ARPP21-028	ARPP21-030

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARPP21-001 ENSP00000187397 ENST00000187397	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	812 aa 89.2 kDa	No	0
ARPP21-002 ENSP00000405276 ENST00000444190	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	793 aa 86.1 kDa	No	0
ARPP21-003 ENSP00000412411 ENST00000428373	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-004 ENSP00000390151 ENST00000412048	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-005 ENSP00000379742 ENST00000396482	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-006 ENSP00000412326 ENST00000417925	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0034605 [cellular response to heat] Show all	813 aa 88.6 kDa	No	0
ARPP21-008 ENSP00000379741 ENST00000396481	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-009 ENSP00000406964 ENST00000441454	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-012 ENSP00000397720 ENST00000436702	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-013 ENSP00000411644 ENST00000450234	C9J5R1 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.4 kDa	No	0
ARPP21-015 ENSP00000398598 ENST00000421492	C9J2U3 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.4 kDa	No	0
ARPP21-016 ENSP00000389754 ENST00000432682	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-017 ENSP00000401602 ENST00000427542	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-018 ENSP00000410171 ENST00000438071	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-021 ENSP00000409808 ENST00000449196	C9JQQ6 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 6.1 kDa	No	0
ARPP21-022 ENSP00000413005 ENST00000419330	C9JTX6 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.7 kDa	No	0
ARPP21-023 ENSP00000409331 ENST00000438577	C9JTF2 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.3 kDa	No	0
ARPP21-024 ENSP00000412341 ENST00000432450	C9J091 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11 kDa	No	0
ARPP21-025 ENSP00000396324 ENST00000452563	C9JD93 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.5 kDa	No	0
ARPP21-027 ENSP00000417838 ENST00000474696	Q9UBL0 [Direct mapping] cAMP-regulated phosphoprotein 21 A8K1F3 [Target identity:100%; Query identity:100%] Cyclic AMP-regulated phosphoprotein, 21 kD, isoform CRA_a; cDNA FLJ30502 fis, clone BRAWH2000482, highly similar to cAMP-regulated phosphoprotein 21; cDNA FLJ78374 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0005516 [calmodulin binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	89 aa 9.7 kDa	No	0
ARPP21-028 ENSP00000390169 ENST00000413378	C9JI74 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.7 kDa	No	0
ARPP21-030 ENSP00000408271 ENST00000425289	H7C2X8 [Direct mapping] cAMP-regulated phosphoprotein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] Show all	261 aa 28.1 kDa	No	0