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HPSE

GENERAL INFORMATION

Gene name

 HPSE

Gene description

 Heparanase

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (Karpas-707)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HPSE (HGNC Symbol)

Synonyms

 HPA, HPSE1, HSE1

Description

 Heparanase (HGNC Symbol)

Entrez gene summary

 Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 4

Cytoband

 q21.23

Chromosome location (bp)

 83292461 - 83335153

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173083 (version 83.38)

Entrez gene

 10855

UniProt

 Q9Y251 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y251

Antibodypedia

 HPSE antibodies

PROTEIN BROWSER
HPSE-001
HPSE-002
HPSE-003
HPSE-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HPSE-001
ENSP00000384262
ENST00000405413
Q9Y251 [Direct mapping]
Heparanase Heparanase 8 kDa subunit Heparanase 50 kDa subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004566 [beta-glucuronidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0006029 [proteoglycan metabolic process]
GO:0007160 [cell-matrix adhesion]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0016020 [membrane]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0030194 [positive regulation of blood coagulation]
GO:0030200 [heparan sulfate proteoglycan catabolic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030305 [heparanase activity]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0042060 [wound healing]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0045545 [syndecan binding]
GO:0046983 [protein dimerization activity]
GO:0051797 [regulation of hair follicle development]
GO:0051798 [positive regulation of hair follicle development]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060055 [angiogenesis involved in wound healing]
GO:0061042 [vascular wound healing]
Show all
 543 aa
61.1 kDa 		Yes 0
HPSE-002
ENSP00000308107
ENST00000311412
Q9Y251 [Direct mapping]
Heparanase Heparanase 8 kDa subunit Heparanase 50 kDa subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004566 [beta-glucuronidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0006029 [proteoglycan metabolic process]
GO:0007160 [cell-matrix adhesion]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0016020 [membrane]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0030194 [positive regulation of blood coagulation]
GO:0030200 [heparan sulfate proteoglycan catabolic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030305 [heparanase activity]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045545 [syndecan binding]
GO:0046983 [protein dimerization activity]
GO:0051797 [regulation of hair follicle development]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 543 aa
61.1 kDa 		Yes 0
HPSE-003
ENSP00000421365
ENST00000513463
Q9Y251 [Direct mapping]
Heparanase Heparanase 8 kDa subunit Heparanase 50 kDa subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004566 [beta-glucuronidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0006029 [proteoglycan metabolic process]
GO:0007160 [cell-matrix adhesion]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0016020 [membrane]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0030194 [positive regulation of blood coagulation]
GO:0030200 [heparan sulfate proteoglycan catabolic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030305 [heparanase activity]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045545 [syndecan binding]
GO:0046983 [protein dimerization activity]
GO:0051797 [regulation of hair follicle development]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 485 aa
54.7 kDa 		Yes 0
HPSE-005
ENSP00000423265
ENST00000512196
Q9Y251 [Direct mapping]
Heparanase Heparanase 8 kDa subunit Heparanase 50 kDa subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004566 [beta-glucuronidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0006029 [proteoglycan metabolic process]
GO:0007160 [cell-matrix adhesion]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0016020 [membrane]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0030194 [positive regulation of blood coagulation]
GO:0030200 [heparan sulfate proteoglycan catabolic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030305 [heparanase activity]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045545 [syndecan binding]
GO:0046983 [protein dimerization activity]
GO:0051797 [regulation of hair follicle development]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 469 aa
53.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.