Cell atlas - COQ2 - The Human Protein Atlas

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COQ2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	COQ2
Gene description	Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056599
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056599	A-431	Cytosol
	HPA056599	U-2 OS	Cytosol

GENE INFORMATION
Gene name	COQ2 (HGNC Symbol)
Synonyms	CL640, FLJ26072
Description	Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband	q21.23
Chromosome location (bp)	83261536 - 83284914
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173085 (version 83.38)
Entrez gene	27235
UniProt	Q96H96 (UniProt - Evidence at protein level)
neXtProt	NX_Q96H96
Antibodypedia	COQ2 antibodies

PROTEIN BROWSER

COQ2-001	COQ2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COQ2-001 ENSP00000310873 ENST00000311469	Q96H96 [Direct mapping] 4-hydroxybenzoate polyprenyltransferase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0002083 [4-hydroxybenzoate decaprenyltransferase activity] GO:0004659 [prenyltransferase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006071 [glycerol metabolic process] GO:0006744 [ubiquinone biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0047293 [4-hydroxybenzoate nonaprenyltransferase activity] Show all	421 aa 45.6 kDa	No	8
COQ2-003 ENSP00000311835 ENST00000311461	E2QRG7 [Direct mapping] 4-hydroxybenzoate polyprenyltransferase, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004659 [prenyltransferase activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	328 aa 35.5 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.