Expression of ADCK5 in cancer - Summary - The Human Protein Atlas

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ADCK5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADCK5
Gene description	AarF domain containing kinase 5
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA025692 , HPA028679
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025692	HPA028679

GENE INFORMATION
Gene name	ADCK5 (HGNC Symbol)
Synonyms	FLJ35454
Description	AarF domain containing kinase 5 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144373101 - 144393242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173137 (version 83.38)
Entrez gene	203054
UniProt	Q3MIX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q3MIX3
Antibodypedia	ADCK5 antibodies

PROTEIN BROWSER

ADCK5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADCK5-001 ENSP00000310547 ENST00000308860	Q3MIX3 [Direct mapping] Uncharacterized aarF domain-containing protein kinase 5 Show all	Enzymes Kinases Atypical kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] Show all	580 aa 65.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.