Expression of MRPL57 in cancer - Summary - The Human Protein Atlas

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MRPL57

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPL57
Gene description	Mitochondrial ribosomal protein L57
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular, mitochondria pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA039779
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039779

GENE INFORMATION
Gene name	MRPL57 (HGNC Symbol)
Synonyms	MRP63
Description	Mitochondrial ribosomal protein L57 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	21176645 - 21179084
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173141 (version 83.38)
Entrez gene	78988
UniProt	Q9BQC6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQC6
Antibodypedia	MRPL57 antibodies

PROTEIN BROWSER

MRPL57-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL57-001 ENSP00000310726 ENST00000309594	Q9BQC6 [Direct mapping] Ribosomal protein 63, mitochondrial A0A024RDM4 [Target identity:100%; Query identity:100%] Mitochondrial ribosomal protein 63, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005761 [mitochondrial ribosome] GO:0006412 [translation] GO:0032543 [mitochondrial translation] Show all	102 aa 12.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.