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ESRRA

GENERAL INFORMATION

Gene name

 ESRRA

Gene description

 Estrogen-related receptor alpha

Protein class

 Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ESRRA (HGNC Symbol)

Synonyms

 ERR1, ERRa, ERRalpha, ESRL1, NR3B1

Description

 Estrogen-related receptor alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64305572 - 64316743

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173153 (version 83.38)

Entrez gene

 2101

UniProt

 P11474 (UniProt - Evidence at protein level)

neXtProt

 NX_P11474

Antibodypedia

 ESRRA antibodies

PROTEIN BROWSER
ESRRA-001
ESRRA-002
ESRRA-003
ESRRA-004
ESRRA-006
ESRRA-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ESRRA-001
ENSP00000385971
ENST00000406310
P11474 [Direct mapping]
Steroid hormone receptor ERR1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0019904 [protein domain specific binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045171 [intercellular bridge]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 422 aa
45.4 kDa 		No 0
ESRRA-002
ENSP00000000442
ENST00000000442
P11474 [Direct mapping]
Steroid hormone receptor ERR1
Q569H8 [Target identity:100%; Query identity:100%]
ESRRA protein; Estrogen-related nuclear receptor alpha; Estrogen-related receptor alpha; HCG2016877, isoform CRA_b
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0019904 [protein domain specific binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045171 [intercellular bridge]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 423 aa
45.5 kDa 		No 0
ESRRA-003
ENSP00000384851
ENST00000405666
P11474 [Direct mapping]
Steroid hormone receptor ERR1
Q569H8 [Target identity:100%; Query identity:100%]
ESRRA protein; Estrogen-related nuclear receptor alpha; Estrogen-related receptor alpha; HCG2016877, isoform CRA_b
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0019904 [protein domain specific binding]
GO:0030278 [regulation of ossification]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032355 [response to estradiol]
GO:0042127 [regulation of cell proliferation]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045171 [intercellular bridge]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051216 [cartilage development]
GO:1900078 [positive regulation of cellular response to insulin stimulus]
Show all
 423 aa
45.5 kDa 		No 0
ESRRA-004
ENSP00000441970
ENST00000468670
F5GWT5 [Direct mapping]
Steroid hormone receptor ERR1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0043565 [sequence-specific DNA binding]
GO:0045171 [intercellular bridge]
Show all
 109 aa
11.2 kDa 		No 0
ESRRA-006
ENSP00000444710
ENST00000545035
H0YGT3 [Direct mapping]
Steroid hormone receptor ERR1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 198 aa
21.3 kDa 		No 0
ESRRA-007
ENSP00000439896
ENST00000539594
F5H0E9 [Direct mapping]
Steroid hormone receptor ERR1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 162 aa
17.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.