Expression of ADAMTS20 in cancer - Summary - The Human Protein Atlas

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ADAMTS20

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAMTS20
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 20
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (Karpas-707, NTERA-2, U-266/70, U-266/84)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA027608 , HPA027609
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027608	HPA027609

GENE INFORMATION
Gene name	ADAMTS20 (HGNC Symbol)
Synonyms	GON-1
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 20 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]
Chromosome	12
Cytoband	q12
Chromosome location (bp)	43353866 - 43551921
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173157 (version 83.38)
Entrez gene	80070
UniProt	P59510 (UniProt - Evidence at transcript level)
neXtProt	NX_P59510
Antibodypedia	ADAMTS20 antibodies

PROTEIN BROWSER

ADAMTS20-001	ADAMTS20-002	ADAMTS20-003	ADAMTS20-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS20-001 ENSP00000374071 ENST00000389420	P59510 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 20 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0009967 [positive regulation of signal transduction] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0043066 [negative regulation of apoptotic process] GO:0045636 [positive regulation of melanocyte differentiation] GO:0048070 [regulation of developmental pigmentation] Show all	1910 aa 214.7 kDa	Yes	0
ADAMTS20-002 ENSP00000448341 ENST00000553158	G3V1X8 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 20; ADAM metallopeptidase with thrombospondin type 1 motif, 20, isoform CRA_c Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1504 aa 169.5 kDa	Yes	0
ADAMTS20-003 ENSP00000447427 ENST00000549670	H0YHN3 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 20 Show all	Predicted intracellular proteins Show all		634 aa 71.7 kDa	No	0
ADAMTS20-201 ENSP00000378911 ENST00000395541	E9PBD5 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 20 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1504 aa 169.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.