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ADCY5

GENERAL INFORMATION

Gene name

 ADCY5

Gene description

 Adenylate cyclase 5

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (MCF7, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (heart muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA017730
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017730

GENE INFORMATION

Gene name

 ADCY5 (HGNC Symbol)

Synonyms

 AC5

Description

 Adenylate cyclase 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 3

Cytoband

 q21.1

Chromosome location (bp)

 123282296 - 123449758

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173175 (version 83.38)

Entrez gene

 111

UniProt

 O95622 (UniProt - Evidence at protein level)

neXtProt

 NX_O95622

Antibodypedia

 ADCY5 antibodies

PROTEIN BROWSER
ADCY5-001
ADCY5-002
ADCY5-003
ADCY5-004
ADCY5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADCY5-001
ENSP00000419361
ENST00000462833
O95622 [Direct mapping]
Adenylate cyclase type 5
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Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001973 [adenosine receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [synaptic transmission]
GO:0007626 [locomotory behavior]
GO:0008179 [adenylate cyclase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019933 [cAMP-mediated signaling]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050885 [neuromuscular process controlling balance]
GO:0055085 [transmembrane transport]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0071377 [cellular response to glucagon stimulus]
GO:0072372 [primary cilium]
GO:1904322 [cellular response to forskolin]
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 1261 aa
138.9 kDa 		No >9
ADCY5-002
ENSP00000418537
ENST00000491190
B3KWA8 [Direct mapping]
Adenylate cyclase type 5; cDNA FLJ42701 fis, clone BRAMY3004919, highly similar to Adenylate cyclase type 5 (EC 4.6.1.1)
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0000166 [nucleotide binding]
GO:0004016 [adenylate cyclase activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 919 aa
103.9 kDa 		No 7
ADCY5-003
ENSP00000308685
ENST00000309879
O95622 [Direct mapping]
Adenylate cyclase type 5
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [synaptic transmission]
GO:0008179 [adenylate cyclase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019933 [cAMP-mediated signaling]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0071377 [cellular response to glucagon stimulus]
GO:0072372 [primary cilium]
GO:1904322 [cellular response to forskolin]
Show all
 911 aa
102.6 kDa 		No 7
ADCY5-004
ENSP00000420082
ENST00000466617
C9JRT8 [Direct mapping]
Adenylate cyclase type 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0000166 [nucleotide binding]
GO:0004016 [adenylate cyclase activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 492 aa
55.5 kDa 		No 4
ADCY5-005
ENSP00000420252
ENST00000483566
C9JQ38 [Direct mapping]
Adenylate cyclase type 5
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Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 90 aa
10.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.